Body weight‐based initial dosing of tacrolimus in renal transplantation: Is this an ideal approach?
نویسندگان
چکیده
منابع مشابه
Tacrolimus in renal transplantation.
The early studies with tacrolimus. from 1989 through 1991, included a pilot series, a small randomized trial, and a larger nonrandomized group. I.3.4 When the outcome of these patients was compared with that in a roughly concurrent (although somewhat less challenging) group of cyclosporine (CyA)-treated patients, equivalent patient and graft survival rates were seen. However, improved secondary...
متن کاملTacrolimus (Pan Graf) in live related renal transplantation: an initial experience of 101 recipients in India.
BACKGROUND Success of modern transplantation is in large part due to the successful development of effective immunosuppressive agents. The safety and efficacy of tacrolimus in transplantation is well established. However, tacrolimus (Pan Graf, Panacea Biotec Ltd, India) has only been available in India for the last 2 years. This study was conducted to assess the safety and efficacy of tacrolimu...
متن کاملTacrolimus nephrotoxicity after renal transplantation.
THIS study describes the clinical profile of tacrolimus (Tac) nephrotoxicity after renal transplantation. Tac was given initially as a 0,075 to 0.1 mg/kg/day IV continuous infusion and then orally at 0.15 mglkg twice daily. Patients were selected based on a rising serum creatinine. normal ultrasound, and absence of rejection on biopsy, leading to a reduction in Tac dosage and fall in creatinine...
متن کاملGut Microbiota and Tacrolimus Dosing in Kidney Transplantation
Tacrolimus dosing to establish therapeutic levels in recipients of organ transplants is a challenging task because of much interpatient and intrapatient variability in drug absorption, metabolism, and disposition. In view of the reported impact of gut microbial species on drug metabolism, we investigated the relationship between the gut microbiota and tacrolimus dosing requirements in this pilo...
متن کاملTacrolimus-based immunosuppression in pediatric renal transplantation.
TACROLIMUS has been shown to be a safe and effective immunosuppressive agent in adult renal transplantation with significant advantages, including the ability to taper corticosteroids in up to 65% of recipients. 1-4 The use of this agent in the pediatric population is less well described. We and others have previously reported that its use in pediatric patients is associated with excellent pati...
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ژورنال
عنوان ژورنال: Journal of Renal Care
سال: 2020
ISSN: 1755-6678,1755-6686
DOI: 10.1111/jorc.12339